piRNAs and PIWI proteins

PIWI proteins and PIWI-interacting RNAs (piRNAs) are essential for silencing mobile genetic elements like transposons in the animal germline and are essential for fertility in animals and humans. Recent advances in structural biology have provided unprecedented molecular insights into the pathway. The use of hamsters has revealed the dangers of relying on mice as the sole representative for mammalian piRNA studies. While the role of piRNAs in gene regulation within the germline and in soma is now firmly established, the molecular insights are only starting to be uncovered. To be able to benefit from these new developments, the community must meet regularly.